Profilerande miRNA i exosomer frigjorda från bruna adipocyter och i exosomer Ett av dessa exosomala miRNAs, miR-92a, är också närvarande i humana

MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science. 2009; 324:1710–1713. doi: 10.1126/science.1174381 Crossref Medline Google Scholar; 18. Zhang L, Zhou M, Wang Y, Huang W, Qin G, Weintraub NL, Tang Y. miR-92a inhibits vascular smooth muscle cell apoptosis: role of the MKK4-JNK pathway. Apoptosis.

2021-02-20 · MiRNA-92a was 0.74-fold and 0.80-fold underexpressed when GLS was silenced in LN229 and T98G cells. Properly, depleting endogenous miRNA-92a-3p inhibits the rate of cell viability, cell migration, and metastasis of U87 and U251 glioma cells in vitro while diminishing tumour volume and weight of xenograft in vivo . miR-92a-3p is also secreted by liposarcoma cells through extracellular vesicles and participates in pro-tumoral inﬂammatory process leading to liposarcoma growth in a paracrine manner. In addition, correlation between miR-92a and cardiovascular disease was reported. The mirVanaTM qRT-PCR miRNA Detection Kit (Ambion) was used in conjunction with quantitative real-time PCR with SYBR Green I for quantification of miR-17, miR-20a and miR-92a transcripts, as detailed elsewhere (Yang et al., 2007). Firstly, we performed qPCR to examine the expression of miRNA‐92a‐1‐5p, miRNA‐375, miR‐148a‐3p in different PCa cells. We found all three miRNAs were universally expressed, but at different level, in the three PCa cell lines (Figure S7a‐c ).

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Keywords Related articles: LINC00467 promotes proliferation and invasion in glioma via interacting with miRNA … 2021-03-05 2017-11-22 2012-05-01 2015-10-13 We suspect that the interactions between miR-92a and ΔSP1 may result from (i) possible G-U wobble base-pairings between the mutated nucleotides and miR-92a; and (ii) extensive base-pairing in the non-seed region of miR-92a (Fig. 1), because the non-seed region of miRNAs (nucleotides 12–17) have been shown in mammalian cells to be important for miRNA targeting [22, 23].

The study of microRNA is growing rapidly as researchers discover new microRNAs and uncover the importance of these small regulatory elements linked to a

Zudem ist die Effektivität der LNA-92a-Applikation für die miRNA-Modifikation und damit den zukünftigen 31 May 2017 MicroRNAs (miRNAs) are small non-coding RNAs that function as post- transcriptional gene expression regulators. The expression profiling of The DNA/RNA hybrids are then captured by a microtiter plate-immobilized monoclonal antibody specific to perfectly matched DNA/miRNA hybrids.

Concurrently, investigators will measure miR 92a/miR 210 levels in all subjects at Extracellular microRNA: Biomarkers of Endothelial Dysfunction in Obese

Gut . 2019 Oct;68(10):1751-1763. doi: 10.1136/gutjnl-2017-315318. 2020-09-20 · MiR-92a and down-regulated FBXW7 reversed cell phenotypes caused by lncRNA MT1JP by rescue analysis. MiRNA target prediction software, TargetScan, revealed dysferlin (DYSF) and protein kinase cAMP-activated catalytic subunit alpha (PRKACA), as target genes of miR-92a-1-5p. 2021-02-20 · MiRNA-92a was 0.74-fold and 0.80-fold underexpressed when GLS was silenced in LN229 and T98G cells.

The plasma Hsa-mir-92a-3p level was related to activated partial thromboplastin time, prothrombin activity, and plasma lipocalin-2 level.
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Firstly, we performed qPCR to examine the expression of miRNA‐92a‐1‐5p, miRNA‐375, miR‐148a‐3p in different PCa cells. We found all three miRNAs were universally expressed, but at different level, in the three PCa cell lines (Figure S7a‐c ). miR-92a is reported as an atheroprone miR involved in inflammasome activation in ECs. 21 To explore whether endothelial miR-92a is the mediator for atherogenic EC-induced macrophage inflammation, we investigated miR-92a biogenesis (primary miR [pri-miR]-92a and mature miR-92a) in cocultured ECs and macrophages.

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miRNA-92a-3p Regulates Osteoblast Differentiation in Patients with Concomitant Limb Fractures and Traumatic Brain Injury Through IBSP/PI3K-AKT Inhabitation LiangcongHu1# JingLiu1# HangXue1# Adriana C.Panayi2 XudongXie 1 ZeLin1 TiantianWang3 YuanXiong1 YiqiangHu1 ChengchengYan1 LangChen1 AbudulaAbududilibaier1 WuZhou1 BobinMi1 GuohuiLiu1

MiRNA-92a promotes cell proliferation and invasion through binding to KLF4 in glioma. Liu PJ(1), Ye YX, Wang YX, Du JX, Pan YH, Fang XB. Author information: (1)Department of Oncological Radiotherapy, the Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.

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A selection of potential CSF-based miRNA marker candidates for PCNSL was obtained by compiling miRNAs expressed in diffuse large B-cell lymphomas and primary CNS lymphomas, based on published miRNA expression data in lymphoma tissues. 20,21 This process resulted in 6 candidate miRNAs (miR-15b, miR-19b, miR-21, miR-92a, miR-106b, miR-204) for further investigation.

;gl9sod 5odw,92a:p.c l52 4xnpfp,g 4as, Profilerande miRNA i exosomer frigjorda från bruna adipocyter och i exosomer Ett av dessa exosomala miRNAs, miR-92a, är också närvarande i humana 29 juni 2020 — We identified microRNA target networks which, when suppressed, miRNAs, such as miR-1246, miR-221-3p, miR-20a, and miR-92a, etc., are Runaway raffle with gin prize. Quantitation of microRNA‑92a in colorectal adenocarcinoma Bild. Quantitation of microRNA‑92a in colorectal adenocarcinoma . MicroRNA-17-92 reglerar myoblastproliferation och -differentiering genom att rikta sig till ENH1 / Id1-signalaxeln. A-Traktorer - Lund - 13/03/2017 46000.00 kr.